NATIONAL CHENG KUNG UNIVERSITY, TAINAN, TAIWAN
BANYAN
Volume 30 Issue 2 - February 5, 2016
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Commentary
Article Digest
Chung-Yen Kuo
Monitoring Vertical Land Motions in Southwestern Taiwan with Retracked Topex/Poseidon and Jason-2 Satellite Altimetry
Hua-Wei Huang
Disclosing Material Weakness in Internal Controls: Does the Gender of Audit Committee Members Matter?
Yau-Sheng Tsai
Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
K.-H. Kao
High Performance Poly Si Junctionless Transistors with Sub-5nm Conformally Doped Layers by Molecular Monolayer Doping and Microwave Incorporating CO2 Laser Annealing for 3D Stacked ICs Applications
News Release
NCKU Press Center
Ecological Genetics and Genomics journal launched in NCKU
NCKU Press Center
A Magic Garden in Tainan Canal
News Release
NCKU Press Center
MovISee opens today at NCKU Art Center
NCKU Press Center
NCKU professor’s research on cancer mechanism published in Cell Metabolism
NCKU Press Center
NCKU initiates its master program on techno art
NCKU Press Center
NCKU student designs a portable wind turbine
NCKU Press Center
NCKU students propose plans to fix underpass flooding problem
NCKU Press Center
France’s renewable energy expert visits Taiwan’s NCKU
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NCKU professor’s research on cancer mechanism published in Cell Metabolism
NCKU Press Center
[Tainan, Taiwan, January 19, 2016]
A study from National Cheng Kung University (NCKU) professor Dr. I-Chen Peng demonstrated an unexpected role of Myc in inducing glutamine synthesis and suggested a molecular connection between DNA demethylation and glutamine metabolism in Myc driven cancers.

According to Dr. Peng, c-Myc is known to promote glutamine usage by upregulating glutaminase (GLS), which converts glutamine to glutamate that is catabolized in the TCA cycle.

Dr. Peng, a professor of life sciences, whose research interests are on targeting lipid and glutamine metabolism to treat obesity and obesity-related diseases, particularly the molecular mechanisms of AMPK, Myc and epigenetic regulation of lipogenesis and glutamine metabolism in adipocytes, hepatocytes and cancer cells.

Her study revealed that in a number of human and murine cells and cancers, Myc induces elevated expression of glutamate-ammonia ligase (GLUL), also termed glutamine synthetase (GS), which catalyzes the de novo synthesis of glutamine from glutamate and ammonia.

Dr. Peng said, this is through upregulation of a Myc transcriptional target thymine DNA glycosylase (TDG), which promotes active demethylation of the GS promoter and its increased expression.

Elevated expression of GS promotes cell survival under glutamine limitation, while silencing of GS decreases cell proliferation and xenograft tumor growth, she added.

Upon GS overexpression, increased glutamine enhances nucleotide synthesis and aminoacid transport.

The study which is published in the journal “Cell Metabolism” in December 2015 offers insight into Myc driven cancers.

Dr. Peng received her B.S. and M.S. degrees from the Department of Agricultural Chemistry at National Taiwan University. She received her Ph.D. in the Biochemistry and Molecular Biology Graduate Program from University of California at Riverside, USA, and the post-doctoral training in the Department of Molecular Genetics & Microbiology at Stony Brook University in New York, USA.
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