Volume 27 Issue 7 - October 10, 2014
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Yung-nane Yang
Systemic flaws imperil food safety
Article Digest
Jui-Hsiang Liu
Multistimuli-Responsive Organogels Based on a Chiral Azo GelatorWithout Hydrogen Bond Assistance
Li-Mei Chen
Longitudinal changes of formant values and vowel space: 0-9 years of age
Sun-Yuan Hsieh
Multi-prefix trie: a new data structure for designing dynamic router-tables
Po-See Chen
5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model
News Release
NCKU Press Center
NCKU research team reveals key mechanism in lung cancer
NCKU Press Center
NCKU research team develops new, low-cost battery voltage detector
News Release
NCKU Press Center
NCKU hosts symposium on university and transportation museum
NCKU Press Center
NCKU hosts international forum on orange technology
NCKU Press Center
NCKU hosts APEC marine environment meeting
NCKU Press Center
Indonesia’s marine ministry delegation visits NCKU
NCKU Press Center
NCKU annual charity second hand book sale a boon for book lovers
NCKU Press Center
NCKU Office of Student Affairs stresses traffic safety as school begins
Banyan Forum
Editorial Group
NCKU research team reveals key mechanism in lung cancer
NCKU Press Center
[Tainan, Taiwan, September 25, 2014]
Lung cancer remains one of the most common and malignant cancers worldwide. A Tainan-based research team from National Cheng Kung University (NCKU) has discovered Rab37, a protein in humans which is a critical regulator of vesicle trafficking, has played a vital role in inhibition of cancer metastasis.

The team led by NCKU Distinguished Professor Dr. Yi-Ching Wang from the Department of Pharmacology and Institute of Basic Medical Science, College of Medicine, made major medical breakthrough in tumour treatment, the university revealed at a press conference in Taipei on September 25.

Their research titled “Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis” has been published in the September issue of Nature Communications.

“What we've discovered will help clinicians to better treat patients with lung cancer,” said Dr. Wang.

She noted that Rab-controlled trafficking pathways have been involved in tumorigenesis.

She also explained, Rab37 suppresses metastasis by regulating the exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1) to repress matrix metalloproteinase 9 (MMP9) and represents a novel prognostic marker for lung cancer.

“We address the metastasis suppressive function of Rab37 using secretomics, cell, animal and clinical analyses,” Dr. Wang added.

The study shows that TIMP1is a novel cargo of Rab37, according to Dr. Wang, and lung cancer patients with metastasis show low Rab37 protein expression coinciding with low TIMP1 in tumours.

Dr. Wang’s team has identified Rab37 as a novel metastasis suppressor Rab that functions through the TIMP1-MMP9 pathway and has significant prognostic power.
Copyright National Cheng Kung University