This paper presents an experimental and theoretical investigation of nonlinear water wave propagation over a sloping bed. Firstly, a series of monochromatic wave laboratory experiments were performed in order to measure the particle trajectories, evolution of wave profile, and wave phase velocity as wave propagates on a sloping bottom. The particle trajectories are quantified by means of images …

Vicariance events caused by geographical barriers, such as sea and mountain ranges, usually result in genetic differentiation between separated populations due to reduction of gene flow and dispersal. As freshwater fishes are strictly constrained by drainage systems, their genetic structures are easy to be influenced by historical changes of environments. In East Asia, how the genetic structure …

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with poor prognosis. The SRY (sex determining region Y)-box 17 (SOX17) gene, encoding a transcription factor containing a high-mobility group DNA-binding domain, is hypermethylated in many cancers. Here we show the low protein expression of SOX17 and its dysregulation of transcriptional network in ESCC. SOX17 protein expression was …

Annotating protein functions and linking proteins with similar functions are important in systems biology. The rapid growth rate of newly sequenced genomes calls for the development of computational methods to help experimental techniques. Phylogenetic profiling (PP) is a method that exploits the evolutionary co-occurrence pattern to identify functional related proteins. However, PP-based methods …