Volume 28 Issue 2 - December 19, 2014 PDF
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Research Express@NCKU Dec. 19 ~ Dec. 30, 2014

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Experimental and Lagrangian modeling of nonlinear water waves propagation on a sloping bottom
Yang-Yih Chen

This paper presents an experimental and theoretical investigation of nonlinear water wave propagation over a sloping bed. Firstly, a series of monochromatic wave laboratory experiments were performed in order to measure the particle trajectories, evolution of wave profile, and wave phase velocity as wave propagates on a sloping bottom. The particle trajectories are quantified by means of images …

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Diverse processes shape deep phylogeographical divergence in Cobitis sinensis (Teleostei: Cobitidae) in East Asia
Tzen-Yuh Chiang

Vicariance events caused by geographical barriers, such as sea and mountain ranges, usually result in genetic differentiation between separated populations due to reduction of gene flow and dispersal. As freshwater fishes are strictly constrained by drainage systems, their genetic structures are easy to be influenced by historical changes of environments. In East Asia, how the genetic structure …

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Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression
Yi-Ching Wang

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with poor prognosis. The SRY (sex determining region Y)-box 17 (SOX17) gene, encoding a transcription factor containing a high-mobility group DNA-binding domain, is hypermethylated in many cancers. Here we show the low protein expression of SOX17 and its dysregulation of transcriptional network in ESCC. SOX17 protein expression was …

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Combining Phylogenetic Profiling-Based and Machine Learning-Based Techniques to Predict Functional Related Proteins
Tien-Hao Chang

Annotating protein functions and linking proteins with similar functions are important in systems biology. The rapid growth rate of newly sequenced genomes calls for the development of computational methods to help experimental techniques. Phylogenetic profiling (PP) is a method that exploits the evolutionary co-occurrence pattern to identify functional related proteins. However, PP-based methods …

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