Volume 27 Issue 6 - September 26, 2014 PDF
Estimation of Potential Gain in Quality of Life from Early Detection of Cervical Cancer
Mei-Chuan Hung1, Ching-Lin Wu 2, Yu-Yun Hsu2, Jing-Shiang Hwang3, Ya-Min Cheng4, Jung-Der Wang1,5,*
1 Department of Public Health, National Cheng Kung University College of Medicine
2 Department of Nursing, College of Medicine, National Cheng Kung University
3 Institute of Statistical Science, Academia Sinica
4 Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University
5 Departments of Internal Medicine and Occupational and Environmental Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University
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Each year, about 528,000 new cases of cervical cancer are reported worldwide. In Taiwan, a screening program exists for early detection, which can reduce about 50% with incidence rate of invasive cervical cancer (ICC) and save life-years for those individuals who are affected, but the effect on quality of life still remains to be quantified.

Investigators abstracted data of 22,543 new cases of ICC from the Taiwan National Cancer Registry dunning 1998-2007 to estimate the lifetime survival function, as well as a consecutive, cross-sectional sample of 421 patients with ICC or carcinoma in situ (CIS) to measure the QOL using World Health Organization Quality of Life- brief version. The ratio of QOL score functions for ICC and CIS patients were summed up over lifetime to obtain the duration of suffering from unsatisfactory HRQL.

In comparison with invasive cervical cancer, early detection of cervical neoplasm at the pre-cancer (carcinoma in situ, CIS) stage not only avoids 6.48 years of life loss, but also prevents reduction in HRQL in the long-run, leading to HRQL gains in the physical (1.71 years) and psychological (0.25 years) domains, as well as sexual life (1.47 years).This is the first study in the world developing method to quantify the duration of HRQL advantage for early detection of cancer.
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