Abdominal aortic aneurysm (AAA) represents a degenerative process of the abdominal aorta and is a common disease in the elderly population with estimates of prevalence ranging 5% to 10%. Despite an improved understanding of the pathophysiology, physicians remain incapable of modifying the natural history of AAA development. Therapeutic strategies to alter the course of AAA must be aimed at the …

Determination of the binding affinity of a protein-ligand complex is important to quantitatively specify whether a particular small molecule will bind to the target protein. In the past decades, several databases of protein-ligand binding affinities have been created via visual extraction from literature. However, such approaches are time-consuming and most of these databases are updated only …

This study introduced a microneedle transdermal delivery system, composed of embeddable chitosan microneedles and a poly(L-lactide-co-D,L-lactide) (PLA) supporting array, for complete and sustained delivery of encapsulated antigens to the skin (Fig. a). Chitosan microneedles were mounted on the top of the strong PLA supporting array, which can provide mechanical strength to achieve full insertion …

Currently, the near-infrared light (NIR) laser radiated photothermal cancer therapy is an emerging treatment modalities. The literatures reported, the near infrared light region has two biological transparency windows, which are between 650-950 nm (first NIR window) and 1000-1350 nm (second NIR window); with optimal tissue transmission obtained from low scattering and absorption, thus providing …