Hua-Lin Wu
Thrombomodulin (TM), a widely expressing glycoprotein originally identified in vascular endothelium, is an important cofactor in anticoagulant system. We presently have demonstrated that recombinant N-terminal lectinlike domain of TM (rTMD1) functions as a protective agent against sepsis, a leading cause of death in hospitalized patients, caused by Gram-negative bacterial infections. …